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References

  1. Guerrini, M., Shriver, Z., Bisio, A., Naggi, A., Casu, B., Sasisekharan, R. and Torri, G. (2009) The tainted heparin story: an update. Thromb Haemost. 102, 907-911
  2. Guerrini, M., Zhang, Z., Shriver, Z., Naggi, A., Masuko, S., Langer, R., Casu, B., Linhardt, R. J., Torri, G. and Sasisekharan, R. (2009) Orthogonal analytical approaches to detect potential contaminants in heparin. Proc Natl Acad Sci U S A. 106, 16956-16961
  3. Aich, U., Shriver, Z., Tharakaraman, K., Raman, R. and Sasisekharan, R. (2011) Competitive inhibition of heparinase by persulfonated glycosaminoglycans: a tool to detect heparin contamination. Analytical chemistry. 83, 7815-7822
  4. Shriver, Z., Capila, I., Venkataraman, G. and Sasisekharan, R. (2012) Heparin and heparan sulfate: analyzing structure and microheterogeneity. Handb Exp Pharmacol, 159-176
  5. Soundararajan, V., Raman, R., Raguram, S., Sasisekharan, V. and Sasisekharan, R. (2010) Atomic interaction networks in the core of protein domains and their native folds. PLoS One. 5, e9391
  6. Soundararajan, V., Zheng, S., Patel, N., Warnock, K., Raman, R., Wilson, I. A., Raguram, S., Sasisekharan, V. and Sasisekharan, R. (2011) Networks link antigenic and receptor-binding sites of influenza hemagglutinin: mechanistic insight into fitter strain propagation. Scientific reports. 1, 200
  7. Soundararajan, V., Patel, N., Subramanian, V., Sasisekharan, V. and Sasisekharan, R. (2011) The many faces of the YopM effector from plague causative bacterium Yersinia pestis and its implications for host immune modulation. Innate immunity. 17, 548-557
  8. Tharakaraman, K., Robinson, L. N., Hatas, A., Chen, Y. L., Siyue, L., Raguram, S., Sasisekharan, V., Wogan, G. N. and Sasisekharan, R. (2013) Redesign of a cross-reactive antibody to dengue virus with broad-spectrum activity and increased in vivo potency. Proceedings of the National Academy of Sciences of the United States of America. 110, E1555-1564
  9. Myette, J. R., Soundararajan, V., Behr, J., Shriver, Z., Raman, R. and Sasisekharan, R. (2009) Heparin/heparan sulfate N-sulfamidase from Flavobacterium heparinum: structural and biochemical investigation of catalytic nitrogen-sulfur bond cleavage. J Biol Chem. 284, 35189-35200
  10. Myette, J. R., Soundararajan, V., Shriver, Z., Raman, R. and Sasisekharan, R. (2009) Heparin/heparan sulfate 6-O-sulfatase from Flavobacterium heparinum: integrated structural and biochemical investigation of enzyme active site and substrate specificity. J Biol Chem. 284, 35177-35188
  11. Shaya, D., Tocilj, A., Li, Y., Myette, J., Venkataraman, G., Sasisekharan, R. and Cygler, M. (2006) Crystal structure of heparinase II from pedobacter heparinus and its complex with a disaccharide product. J Biol Chem
  12. Artpradit, C., Robinson, L. N., Gavrilov, B. K., Rurak, T. T., Ruchirawat, M. and Sasisekharan, R. (2013) Recognition of heparan sulfate by clinical strains of dengue virus serotype 1 using recombinant subviral particles. Virus research. 176, 69-77
  13. Bulmer, M. S., Bachelet, I., Raman, R., Rosengaus, R. B. and Sasisekharan, R. (2009) Targeting an antimicrobial effector function in insect immunity as a pest control strategy. Proc Natl Acad Sci U S A. 106, 12652-12657
  14. Bosques, C. J., Collins, B. E., Meador, J. W., 3rd, Sarvaiya, H., Murphy, J. L., Dellorusso, G., Bulik, D. A., Hsu, I. H., Washburn, N., Sipsey, S. F., Myette, J. R., Raman, R., Shriver, Z., Sasisekharan, R. and Venkataraman, G. (2010) Chinese hamster ovary cells can produce galactose-alpha-1,3-galactose antigens on proteins. Nature biotechnology. 28, 1153-1156
  15. Chandrasekaran, A., Srinivasan, A., Raman, R., Viswanathan, K., Raguram, S., Tumpey, T. M., Sasisekharan, V. and Sasisekharan, R. (2008) Glycan topology determines human adaptation of avian H5N1 virus hemagglutinin. Nat Biotechnol. 26, 107-113
  16. Srinivasan, K., Raman, R., Jayaraman, A., Viswanathan, K. and Sasisekharan, R. (2013) Quantitative description of glycan-receptor binding of influenza A virus H7 hemagglutinin. PloS one. 8, e49597
  17. Srinivasan, K., Raman, R., Jayaraman, A., Viswanathan, K. and Sasisekharan, R. (2013) Quantitative characterization of glycan-receptor binding of H9N2 influenza A virus hemagglutinin. PloS one. 8, e59550
  18. Pearce, M. B., Jayaraman, A., Pappas, C., Belser, J. A., Zeng, H., Gustin, K. M., Maines, T. R., Sun, X., Raman, R., Cox, N. J., Sasisekharan, R., Katz, J. M. and Tumpey, T. M. (2012) Pathogenesis and transmission of swine origin A(H3N2)v influenza viruses in ferrets. Proceedings of the National Academy of Sciences of the United States of America. 109, 3944-3949
  19. Maines, T. R., Chen, L. M., Van Hoeven, N., Tumpey, T. M., Blixt, O., Belser, J. A., Gustin, K. M., Pearce, M. B., Pappas, C., Stevens, J., Cox, N. J., Paulson, J. C., Raman, R., Sasisekharan, R., Katz, J. M. and Donis, R. O. (2011) Effect of receptor binding domain mutations on receptor binding and transmissibility of avian influenza H5N1 viruses. Virology. 413, 139-147
  20. Viswanathan, K., Koh, X., Chandrasekaran, A., Pappas, C., Raman, R., Srinivasan, A., Shriver, Z., Tumpey, T. M. and Sasisekharan, R. (2010) Determinants of Glycan Receptor Specificity of H2N2 Influenza A Virus Hemagglutinin. PLoS One. 5, e13768
  21. Pappas, C., Viswanathan, K., Chandrasekaran, A., Raman, R., Katz, J. M., Sasisekharan, R. and Tumpey, T. M. (2010) Receptor specificity and transmission of H2N2 subtype viruses isolated from the pandemic of 1957. PLoS One. 5, e11158
  22. Srinivasan, A., Viswanathan, K., Raman, R., Chandrasekaran, A., Raguram, S., Tumpey, T. M., Sasisekharan, V. and Sasisekharan, R. (2008) Quantitative biochemical rationale for differences in transmissibility of 1918 pandemic influenza A viruses. Proc Natl Acad Sci U S A. 105, 2800-2805
  23. Soundararajan, V., Tharakaraman, K., Raman, R., Raguram, S., Shriver, Z., Sasisekharan, V. and Sasisekharan, R. (2009) Extrapolating from sequence–the 2009 H1N1 ‘swine’ influenza virus. Nat Biotechnol. 27, 510-513
  24. Maines, T. R., Jayaraman, A., Belser, J. A., Wadford, D. A., Pappas, C., Zeng, H., Gustin, K. M., Pearce, M. B., Viswanathan, K., Shriver, Z. H., Raman, R., Cox, N. J., Sasisekharan, R., Katz, J. M. and Tumpey, T. M. (2009) Transmission and pathogenesis of swine-origin 2009 A(H1N1) influenza viruses in ferrets and mice. Science. 325, 484-487
  25. Jayaraman, A., Chandrasekaran, A., Viswanathan, K., Raman, R., Fox, J. G. and Sasisekharan, R. (2012) Decoding the distribution of glycan receptors for human-adapted influenza A viruses in ferret respiratory tract. PloS one. 7, e27517
  26. Aich, U., Beckley, N., Shriver, Z., Raman, R., Viswanathan, K., Hobbie, S. and Sasisekharan, R. (2011) Glycomics-based analysis of chicken red blood cells provides insight into the selectivity of the viral agglutination assay. The FEBS journal. 278, 1699-1712
  27. Lakdawala, S. S., Shih, A. R., Jayaraman, A., Lamirande, E. W., Moore, I., Paskel, M., Sasisekharan, R. and Subbarao, K. (2013) Receptor specificity does not affect replication or virulence of the 2009 pandemic H1N1 influenza virus in mice and ferrets. Virology. 446, 349-356
  28. Sassaki, G. L., Elli, S., Rudd, T. R., Macchi, E., Yates, E. A., Naggi, A., Shriver, Z., Raman, R., Sasisekharan, R., Torri, G. and Guerrini, M. (2013) Human (alpha2–>6) and avian (alpha2–>3) sialylated receptors of influenza A virus show distinct conformations and dynamics in solution. Biochemistry
  29. Hobbie, S. N., Viswanathan, K., Bachelet, I., Aich, U., Shriver, Z., Subramanian, V., Raman, R. and Sasisekharan, R. (2013) Modular glycosphere assays for high-throughput functional characterization of influenza viruses. BMC Biotechnol. 13, 34
  30. Jayaraman, A., Pappas, C., Raman, R., Belser, J. A., Viswanathan, K., Shriver, Z., Tumpey, T. M. and Sasisekharan, R. (2011) A single base-pair change in 2009 H1N1 hemagglutinin increases human receptor affinity and leads to efficient airborne viral transmission in ferrets. PloS one. 6, e17616
  31. Sun, X., Jayaraman, A., Maniprasad, P., Raman, R., Houser, K. V., Pappas, C., Zeng, H., Sasisekharan, R., Katz, J. M. and Tumpey, T. M. (2013) N-linked glycosylation of the hemagglutinin protein influences virulence and antigenicity of the 1918 pandemic and seasonal H1N1 influenza A viruses. Journal of virology. 87, 8756-8766
  32. Jayaraman, A., Koh, X., Li, J., Raman, R., Viswanathan, K., Shriver, Z. and Sasisekharan, R. (2012) Glycosylation at Asn91 of H1N1 haemagglutinin affects binding to glycan receptors. The Biochemical journal. 444, 429-435
  33. Hensley, S. E., Das, S. R., Bailey, A. L., Schmidt, L. M., Hickman, H. D., Jayaraman, A., Viswanathan, K., Raman, R., Sasisekharan, R., Bennink, J. R. and Yewdell, J. W. (2009) Hemagglutinin receptor binding avidity drives influenza A virus antigenic drift. Science. 326, 734-736
  34. Tharakaraman, K., Raman, R., Stebbins, N. W., Viswanathan, K., Sasisekharan, V. and Sasisekharan, R. (2013) Antigenically intact hemagglutinin in circulating avian and swine influenza viruses and potential for H3N2 pandemic. Scientific reports. 3, 1822
  35. Tharakaraman, K., Raman, R., Viswanathan, K., Stebbins, N. W., Jayaraman, A., Krishnan, A., Sasisekharan, V. and Sasisekharan, R. (2013) Structural determinants for naturally evolving H5N1 hemagglutinin to switch its receptor specificity. Cell. 153, 1475-1485
  36. Tharakaraman, K., Jayaraman, A., Raman, R., Viswanathan, K., Stebbins, N. W., Johnson, D., Shriver, Z., Sasisekharan, V. and Sasisekharan, R. (2013) Glycan receptor binding of the influenza A virus H7N9 hemagglutinin. Cell. 153, 1486-1493
  37. Zhu, H., Wang, D., Kelvin, D. J., Li, L., Zheng, Z., Yoon, S.-W., Wong, S. S., Farooqui, A., Wang, J., Banner, D., Chen, R., Zheng, R., Zhou, J., Zhang, Y., Hong, W., Dong, W., Cai, Q., Roehrl, M. H. A., Huang, S. S. H., Kelvin, A. A., Yao, T., Zhou, B., Chen, X., Leung, G. M., Poon, L. L. M., Webster, R. G., Webby, R. J., Peiris, J. S. M., Guan, Y. and Shu, Y. (2013) Infectivity, Transmission, and Pathology of Human H7N9 Influenza in Ferrets and Pigs. Science. 341, 183-6
  38. Xiong, X., Martin, S. R., Haire, L. F., Wharton, S. A., Daniels, R. S., Bennett, M. S., McCauley, J. W., Collins, P. J., Walker, P. A., Skehel, J. J. and Gamblin, S. J. (2013) Receptor binding by an H7N9 influenza virus from humans. Nature. 499, 496-499
  39. Sasisekharan, R. and Shriver, Z. (2009) From crisis to opportunity: a perspective on the heparin crisis. Thromb Haemost. 102, 854-858
  40. Kishimoto, T. K., Viswanathan, K., Ganguly, T., Elankumaran, S., Smith, S., Pelzer, K., Lansing, J. C., Sriranganathan, N., Zhao, G., Galcheva-Gargova, Z., Al-Hakim, A., Bailey, G. S., Fraser, B., Roy, S., Rogers-Cotrone, T., Buhse, L., Whary, M., Fox, J., Nasr, M., Dal Pan, G. J., Shriver, Z., Langer, R. S., Venkataraman, G., Austen, K. F., Woodcock, J. and Sasisekharan, R. (2008) Contaminated Heparin Associated with Adverse Clinical Events and Activation of the Contact System. N Engl J Med
  41. Guerrini, M., Beccati, D., Shriver, Z., Naggi, A., Viswanathan, K., Bisio, A., Capila, I., Lansing, J. C., Guglieri, S., Fraser, B., Al-Hakim, A., Gunay, N. S., Zhang, Z., Robinson, L., Buhse, L., Nasr, M., Woodcock, J., Langer, R., Venkataraman, G., Linhardt, R. J., Casu, B., Torri, G. and Sasisekharan, R. (2008) Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical events. Nat Biotechnol. 26, 669-675

Note: References 37 and 38 are not Sasisekharan Lab publications